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KMID : 0614620020400040282
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Korean Journal of Gastroenterology
2002 Volume.40 No. 4 p.282 ~ p.285
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Acute Pancreatitis Induced by 5-Aminosalicylic Acid in a Patient with Ulcerative Colitis
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이현영/Hyun Young Lhee
김병익/유태우/이호철/정찬희/신헌섭/박승하/김정욱/조용균/이준행/박창영/손정일/전우규/Byung Ik Kim/Tae Woo Yoo/Ho Chul Lee/Chan Hee Jung/Hun Sub Shin/Seung Ha Park/Jung Uk Kim/Yong Kyun Cho/Jun Haeng Lee/Chang Young Park/Chung Il Sohn/Woo Kyu Jeon
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Abstract
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Acute pancreatitis is a rare complication of 5-aminosalicylic acid (5-ASA) treatment. We recently experienced a case of acute pancreatitis secondary to 5-ASA in a patient with ulcerative colitis (UC). A 25-year-old man was admitted for bloody
diarrhea
and lower abdominal pain. Mesalazine was used under the diagnosis of ulcerative colitis, but the symptoms were not improved. After symptomatic improvement by steroid treatment, mesalazine was restarted for maintaining the remission. On the next
day, he
had a sudden severe epigastric pain with elevation of serum amylase and lipase levels. Drug-induced pancreatitis was suspected, and the mesalazine was discontinued. His abdominal pain disappeared, and his serum amylase and lipase levels returned
to
normal. After the administration of sulfasalazine, however, pancreatitis was relapsed. In conclusion, we suggest that drug-induced pancreatitis should be suspected in any patient who develops new abdominal pain while receiving 5-ASA.
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